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The automation of Science

Ross D. King,
Jem Rowland,
Stephen G. Oliver,
Michael Young,
Wayne Aubrey,
Emma Byrne,
Maria Liakata,
Magdalena Markham,
Pınar Pir,
Larisa N. Soldatova,
Andrew Sparkes,
Kenneth E. Whelan,
Amanda Clare
The basis of science is the hypothetico-deductive method and the recording of experiments in
sufficient detail to enable reproducibility. We report the development of Robot Scientist “Adam,”
which advances the automation of both. Adam has autonomously generated functional genomics
hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses
by using laboratory automation. We have confirmed Adam’s conclusions through manual
experiments. To describe Adam’s research, we have developed an ontology and logical language.
The resulting formalization involves over 10,000 different research units in a nested treelike
structure, 10 levels …

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